diff --git a/pcsx2-qt/MainWindow.cpp b/pcsx2-qt/MainWindow.cpp
index 1acf025d0c..3f3739e76d 100644
--- a/pcsx2-qt/MainWindow.cpp
+++ b/pcsx2-qt/MainWindow.cpp
@@ -219,6 +219,9 @@ void MainWindow::setupAdditionalUi()
 	m_ui.actionViewStatusBar->setChecked(status_bar_visible);
 	m_ui.statusBar->setVisible(status_bar_visible);
 
+	const bool show_game_grid = Host::GetBaseBoolSettingValue("UI", "GameListGridView", false);
+	updateGameGridActions(show_game_grid);
+
 	m_game_list_widget = new GameListWidget(getContentParent());
 	m_game_list_widget->initialize();
 	m_ui.actionGridViewShowTitles->setChecked(m_game_list_widget->getShowGridCoverTitles());
@@ -390,6 +393,7 @@ void MainWindow::connectSignals()
 	connect(m_game_list_widget, &GameListWidget::layoutChange, this, [this]() {
 		QSignalBlocker sb(m_ui.actionGridViewShowTitles);
 		m_ui.actionGridViewShowTitles->setChecked(m_game_list_widget->getShowGridCoverTitles());
+		updateGameGridActions(m_game_list_widget->isShowingGameGrid());
 	});
 
 	SettingWidgetBinder::BindWidgetToBoolSetting(nullptr, m_ui.actionViewStatusBarVerbose, "UI", "VerboseStatusBar", false);
@@ -3145,6 +3149,14 @@ void MainWindow::updateGameDependentActions()
 	m_ui.actionReloadPatches->setEnabled(s_vm_valid);
 }
 
+void MainWindow::updateGameGridActions(const bool show_game_grid)
+{
+	m_ui.actionGridViewShowTitles->setEnabled(show_game_grid);
+	m_ui.actionGridViewZoomIn->setEnabled(show_game_grid);
+	m_ui.actionGridViewZoomOut->setEnabled(show_game_grid);
+	m_ui.actionGridViewRefreshCovers->setEnabled(show_game_grid);
+}
+
 void MainWindow::doStartFile(std::optional<CDVD_SourceType> source, const QString& path)
 {
 	if (s_vm_valid)
diff --git a/pcsx2-qt/MainWindow.h b/pcsx2-qt/MainWindow.h
index 5c210f20be..b828680114 100644
--- a/pcsx2-qt/MainWindow.h
+++ b/pcsx2-qt/MainWindow.h
@@ -234,6 +234,7 @@ private:
 	void updateEmulationActions(bool starting, bool running, bool stopping);
 	void updateDisplayRelatedActions(bool has_surface, bool render_to_main, bool fullscreen);
 	void updateGameDependentActions();
+	void updateGameGridActions(const bool show_game_grid);
 	void updateStatusBarWidgetVisibility();
 	void updateAdvancedSettingsVisibility();
 	void updateWindowTitle();